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Chronic Myeloid Leukemia

 

 

Symptoms

Presenting symptoms of CML are not specific and may resemble other leukemias. 

Early CML is usually asymptomatic. 

The three clinical phases (chronic, accelerated and blast crisis), are each associated with different symptoms and duration.

  • Symptoms associated with hyperleukocytosis, hypermetabolism and splenomegaly are frequent
  • Thrombocytopenia and anemia are uncommon
  • Signs of extramedullary hemopoiesis and skin nodules are infrequent

 

Symptoms associated with CML:

Chronic Phase

Lasts for approximately 3 years

 

Most people diagnosed at this stage

 

Nonspecific symptoms:

  • Night sweats
  • Weakness
  • Left upper quadrant pain (enlarged spleen)
  • Bone pain

 

Symptoms associated with hyperleukocytosis:

  • Neurologic dysfunction
  • Visual changes
  • Respiratory distress
  • Priapism

 

Accelerated Phase

Progress gradually or abruptly

 

Progressive systemic symptoms

 

Splenomegaly:

  • Abdominal discomfort
  • Dysphagia
  • Increased abdominal girth

 

Blast Crisis

Rapid deterioration in health to death within a few months

 

 


 

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