Presenting symptoms of CML are not specific and may resemble other leukemias.
Early CML is usually asymptomatic.
The three clinical phases (chronic, accelerated and blast crisis), are each associated with different symptoms and duration.
- Symptoms associated with hyperleukocytosis, hypermetabolism and splenomegaly are frequent
- Thrombocytopenia and anemia are uncommon
- Signs of extramedullary hemopoiesis and skin nodules are infrequent
Symptoms associated with CML:
Chronic Phase |
Lasts for approximately 3 years
Most people diagnosed at this stage
Nonspecific symptoms:
Symptoms associated with hyperleukocytosis:
|
Accelerated Phase |
Progress gradually or abruptly
Progressive systemic symptoms
Splenomegaly:
|
Blast Crisis |
Rapid deterioration in health to death within a few months
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