CML is characterized by:
- Myeloid hyperplasia
- Extramedullary hematopoiesis with splenomegaly
- Leukocytosis.
CML has a unicellular origin but results in a multicellular stem cell neoplastic transformation.
Ph+ chromosome is found in proliferating erythroid, granulocytic, monocytic, megakaryocytic precursor cells but not in fibroblasts or somatic cells.
See Bone Marrow
Bone Marrow Biopsy in CML:
Low power view
