Poorly defined intermediate phase
Half of all patients develop a progressive maturation defect which results in an acute leukemia type picture.
45% of patients undergo a gradual progression to a myeloproliferative syndrome.
Sudden onset to blast phase is unusual in the first 3 years of CML.
Progressive symptoms appear during this phase - fever, night sweats and weight loss.
- Increasing bone marrow and blood leukemic blasts (10 - 19%)
- Cytopenias
- Increasing basophil count
- Progressive myelofibrosis
- Clonal Karyotype evolution
- commonly duplication of Ph chromosome
- isochromosome 17
- trisomy 8
- Refractory to therapy
