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Chronic Myeloid Leukemia

 

 

Prognosis

 

Time to progression of the disease is variable.  Evolution from chronic phase to accelerated phase to blast crisis is a natural course of the disease. 

Duration of the chronic phase is the major determinant of survival time.

Prognostic factors for adults that predict early transformation:

    • Spleen size at diagnosis
    • Hepatomegaly
    • Thrombocytopenia
    • Thrombocytosis
    • Platelet count
    • Circulating myeloblasts
    • Eosinophils and basophil counts

    These prognostic factors cannot be generalized to pediatric CML population.

     

    Survival outcome for blast phase is generally poor and fewer than 15% of patients achieve long-term survival.

     

    Prognostic factors after entering blast phase:

  • Blast cell phenotype
  • Cytogenetic findings

 

Favourable factors include lymphoblastic phenotype and minimal karyotypic evolution.

 

 

 
 


 

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