Imatinib mesylate = STI 571 = Gleevec
This was the first agent designed to be a molecularly specific suppressor of the neoplastic clone.
Small 2-phentylaminopyramidine molecule that inhibits abl tyrosine kinase
This drug blocks the activity of the of bcr/abl protein by occupying the ATP-binding site. This prevents the phosphorylation of abl-tyrosine kinase substrates and prevents activation of downstream leukemogenic signal transduction.
Tyrosine protein kinase inhibitor:
- Imatinib mesylate (BCR-ABL tyrosine protein kinase inhibitor)
- Used for more advanced disease
- Achieve complete hematologic responses
Chronic Myeloid leukemia: Treatment options at the National Cancer Institute
