Morphologic types of ALL - cytologic features:
|
L1 | L2 | L3 |
Cell size |
small predominate |
large heterogenous |
large and heterogenous |
Nuclear Chromatin |
Homogenous | Variable Heterogenous |
Finely stippled & Homogenous |
Nuclear shape |
Regular with occasional clefting or indentation | Irregular. Clefting and indentation common |
Regular oval to round |
Nucleoli |
Not visible or very small | One or more present Often large |
Prominent One or more vesicular |
Amount of cytoplasm |
Scanty | Variable Usually moderately abundant |
Moderately abundant |
Basophilia of cytoplasm |
Slight or moderate Rarely intense |
Variable Deep in some |
Very deep |
Cytoplasmic vacuolation |
Variable | Variable | Often prominent |
