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Supratentorial PNET



Routes of Spread

Spread of supratentorial PNETS can be thought of in terms of:

  • Local:
    • Invasion of adjacent brain
  • CSF pathways:
    • Leptomeninges are often involved in at least 30% of patients at diagnosis or relapse
  • Distant:
    • Extraneural metastases are very uncommon6 (in one series <0.5% had metastases outside the CNS11)
    • Unless patients are symptomatic, bone scans and bone marrow biopsy to detect metastatic disease outside the CNS would not be routinely recommended in patients with newly diagnosed disease

















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