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Supratentorial PNET





The natural history of supratentorial PNETs is difficult to predict with certainty because:

  • Supratentorial PNETs are rare
  • Controversy regarding histological and pathological classification

Long-term survival in supratentorial PNET patients is poor14 and significantly worse than medulloblastoma.

Survival is also influenced by different prognostic factors, (both tumor related and non-tumor related). These factors play an important role in treatment planning25.


Summary of prognostic factors:         






Aged 3 and older


2 year survival rate= 72%


5 year survival rate= 50%

Under age 3


2 year survival rate= 28%


5 year survival rate= 5.8%


*Most likely due to limited use of RT for younger children11


Pineal region


Deep region of CNS


Extent of resection

Gross total resection or near total resection

Subtotal, partial or biopsy type resection
Spread Localized disease Evidence of dissemination17

Treatment method

Aggressive multimodality treatment

The use of multimodality treatment is limited (eg. treatment complications such as infection)

Dose and volume of RT

Treatment to whole CSA

Dose of 3500 cGy to CSA

No RT or low dose RT to CSA


Not shown to be a significant prognostic marker10







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