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Medulloblastoma

 

 

Incidence

Medulloblastoma accounts for 15-20% of all pediatric brain tumors.

First described in 1925 by Bailey and Cushing.

About 250 to 500 children are diagnosed with medulloblastoma each year in the United States.  In children up to 15 years of age the incidence is 0.5 per 100,000.

 

Medulloblastoma is an infratentorial PNET:

  • Malignant, invasive embryonal tumor (Primitive Neuro-Ectodermal Tumor or PNET).
  • By definition, a medulloblastoma is a PNET arising in the posterior fossa and is infratentorial - this means that this tumor arises below the tentorium (see diagram below where S is supratentorial, I is infratentorial and T is the tentorium).
  • In children, medulloblastomas generally arise in the midline of the cerebellum.

Most common between the ages of 4 and 6:

  • 20% of patients less than 2 years old
  • 80% less than 15 years old
  • very unusual in adults, but can occur
  • Slight male predominance (male to female ratio of 3:2)
  • No racial predisposition to this tumor

 

Summary of Facts about the Incidence of Medulloblastoma:

Proportion of pediatric brain tumors

15-20%

Common age of onset

4-6

% of patients less than 2 years old

20%

% of patients less than 15 years old

80%

Gender bias

3:2 male predominance

Racial bias

None

 

 

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