Commonest subtype - affects 40% of children and 70% of adolescents.
- Few neoplastic cells
- Lacunar variant of HRS cells most commonly seen
- Inflammatory cells
- Lymph node capsule is very thickened
- Thick collagenous bands surround cellular nodules.
The slide below shows the microscopic appearance of nodular sclerosis HL
- Usually involves cervical, supraclavicular and mediastinal lymph nodes.