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Hodgkin Lymphoma



Nodular Sclerosis


Commonest subtype - affects 40% of children and 70% of adolescents.


Nodules of:

  • Few neoplastic cells
    • Lacunar  variant of HRS cells most commonly seen
  • Inflammatory cells
  • Lymph node capsule is very thickened
  • Thick collagenous bands surround cellular nodules.


The slide below shows the microscopic appearance of nodular sclerosis HL

Clinical Picture

  • Usually involves cervical, supraclavicular and mediastinal lymph nodes.





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