Mixed Cellularity
Pathology
Intermediate subtype - falls between lymphocyte rich classical Hodgkin lymphoma and lymphocyte depleted.
HRS cells and their variants are common in this subtype.
Tumor has a diffuse or only vaguely nodular pattern and lacks significant fibrosis.
Microscopic apprearance (high power) of mixed cellularity HL:
Clinical Picture
Occurs in roughly 30% of patients - more common in children aged 10 years or younger.
Often presents as advanced disease with extranodal involvement.
