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Rhabdomyosarcoma

Non-RMS

 

 

Ewing Sarcoma

 

 

Fertility

Fertility preservation should be considered and discussed prior to treatment initiation.

 

Cyclophosphamide and ifosphamide are both associated with a high risk of future infertility - especially in males - but females are also at risk.

Pelvic radiotherapy (RT) is also associated with a very significant risk of infertility. This can be limited by:

  • Shielding testes during RT with metal shielding devices that fit around the testes (significantly reduces scattered RT to testes).
  • Ovaries can be moved or "transposed" as far away from the RT field as possible.

 

Sperm donation and cryopreservation should be pursued for post-pubertal boys prior to any chemotherapy.

 

Egg harvesting may be possible for post-pubertal girls (though this technology has been associated with very few successful pregnancies thus far).

 

Reproductive technology continues to improve and new options for fertility preservation even in pre-pubescent females, including ovary harvesting, are being explored.

 

Links:

Fertility preservation (male)

Fertility preservation (female)

 

 

 

 

 

 

 

 

 

 

 

 

 

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