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Acute Myeloid Leukemia

 

 

Classification

 

20% blasts in bone marrow required for diagnosis (WHO).

The following clonal cytogenetic abnormalities considered to have AML regardless of the blast percentage:

 

FAB classification of AML:

Type

Name 

Associated

Chromosomal Abnormality

Associated Immunophenotype on Flow Cytometry

M0

Acute undifferentiated leukemia

 

CD13, CD33, CD34, CD65, HLA-DR, CD117

M1

Myeloblastic leukemia. No maturation

Morphology exactly similar to M2

t(8;21)(q22;q22)

CD13, CD33, CD34, CD65, HLA-DR, CD117

M2

Myeloblastic leukemia with differentiation

t(8;21)(q22;q22)

t(6;9)(p23;q34)

CD33, CD34, CD65, HLA-DR

M3

Acute Promyelocytic Leukemia (APL). Cytoplasm contains multiple rods.

t(15;17)(q22:q21)

CD15, CD33, CD65

M3V

Microgranular varient of APL.

t(15;17)(q22:q21)

 

M4

Both myelocytic and monocytic differentiation present in varying proportions

t(9;11)(p22;q23)

MLL (11q23)

t(6;9)(p23;q34)

CD11b, CD13, CD14, CD15, CD33, CD65, CD36, CD4, HLA-DR

M4EOS

 

inv(16)(p13;q22)

 

M5

 Acute Monoblastic Leukemia

t(9;11)(p22;q23)

MLL (11q23)

CD11b, CD13, CD15, CD33, CD65, CD36, CD4, HLA-DR

M6

 Acute Erythroleukemia

 

CD33, CD65, Glycophorin A

M7

 Acute Megakaryocytic Leukemia

 t(1;22)(p13;q13)

CD33, CD41, CD61, CD42, CD36, CD2

 

Link:

Classification of Pediatric Myeloid Malignancies at the National Cancer Institute

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