Routes of spread for Non-RMS or any tumor can be thought of in terms of:
- Local
- Lymphatic
- Distant
Local
- Invasion of local tissues. This may include:
- Neurovascular bundle
- Very rare to have invasion into bone, but can occur
Lymphatic
Lymphatic spread is generally less common in non-RMS than RMS.
There is an increased risk of lymphatic spread for specific types:
- Epithelioid sarcoma
- Clear cell sarcoma
- Extra-osseous Ewing sarcoma
- Malignant fibrous histiocytoma (pleomorphic sarcoma)
- Synovial sarcoma
- Alveolar soft part sarcoma
Distant
Blood borne metastases are common to the lungs
Less commonly there may be metastatic deposits to bone and soft tissues
