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Non-Rhabdomyosarcoma (Non-RMS)



Routes of Spread



Routes of spread for Non-RMS or any tumor can be thought of in terms of:

  • Local
  • Lymphatic
  • Distant



  • Invasion of local tissues. This may include:
    • Neurovascular bundle
    • Very rare to have invasion into bone, but can occur



Lymphatic spread is generally less common in non-RMS than RMS.

There is an increased risk of lymphatic spread for specific types:

  • Epithelioid sarcoma
  • Clear cell sarcoma
  • Extra-osseous Ewing sarcoma
  • Malignant fibrous histiocytoma (pleomorphic sarcoma)
  • Synovial sarcoma
  • Alveolar soft part sarcoma



Blood borne metastases are common to the lungs

Less commonly there may be metastatic deposits to bone and soft tissues





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