The prognosis of non-RMS tumors varies greatly depending on the histologic grade, invasiveness, tumor size, resectability, use of radiation therapy, site of primary tumor, and presence of metastases.
Prognostic factors
| POOR PROGNOSIS | IMPROVED PROGNOSIS |
Advanced tumor stage
|
Localized disease |
| High histopathological grade | Low histopathological grade |
| Size | Size |
Anatomical depth
|
Anatomical depth
|
Site
|
Site
|
| Positive margin of resection for disease | Tumor widely excised |
| Poor tumor response to therapy | 90% or more necrosis of tumor after therapy |
| No adjuvant radiation therapy | Radiation therapy improves chance of local control |
Results of a pooled analysis of results from United states and European groups:
- Overall survival (OS):
- 60.0% at 5 years
- 51.5% at 10 years
- Significantly associated with patient's age, histological subtype, tumour site and size, quality of delayed surgical resection, radiotherapy administration and response to induction chemotherapy.
MPNST associated to neurofibromatosis type 1 was the tumour type with the worst rate of response to chemotherapy and the worst outcome.
References
Clin Orthop Relat Res. 2010 Nov;468(11):3003-11. doi: 10.1007/s11999-010-1471-9. Do surgical margin and local recurrence influence survival in soft tisse sarcomas? Novais EN, Demiralp B, Alderete J, Larson MC, Rose PS, Sim FH.
