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Neuroblastoma

 

 

Disease Spread and location

 

Neuroblastoma may originate anywhere along the sympathetic chain.

The NCI guide to NBL has an excellent diagram.

 

Location of Primary Neuroblastoma:

Location of Primary Site

Proportion of Tumors

The adrenal

40%

Abdominal paraspinal ganglion

25%

Thoracic paraspinal ganglion

15%

Neck

5%

Pelvis 5%

 

Babies less than 1 year old have a higher proportion of thoracic tumors compared to older children.

Roughly 50% of infants and 70% of older children present with metastatic disease. 

 

The most common sites of metastases are:

  • Lymph nodes (regional and disseminated)
  • Bone marrow
  • Bone
  • Liver
  • Subcutaneous tissue

 

 

 

 

 

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