BM Transplant down arrow

Home > Disclaimer > Bone Marrow Transplant


Bone Marrow Transplant



Allogeneic Hematopoietic Stem Cell Donor Cell


Choosing a donor


Human Leukocyte Antigen (HLA) System: 

This is the most important factor in picking a HSCT donor is in HLA matching between donor and recipient. 

Other Non-HLA Factors Considered When Choosing A Donor:


CMV IgG Status of Donor

  • Cytomegalovirus can be transmitted from a donor into a CMV naive recipient causing CMV disease (hepatitis, chorioretinitis, pneumonia, colitis). 
  • Preferable to use a CMV negative donor if available.


Age, Gender and Parity of Donor

  • Preference for younger donors. 
  • Higher risk when a female donor who has had children is the donor for a male recipient.  This is because anti-HLA antibodies and other non-HLA antibodies may have formed in the female donor from previous pregnancies which may increase the risk of GvHD.


Cell Dose of Umbilical Cords

  • The total nucleated cell count of a cord blood unit (which includes both mature hematopoietic cells and HSCs) is as important as HLA type. 
  • Generally aim for a total nucleated cell count of >2 x 107/kg of recipient body weight.  Lower cell doses have much higher risks of non-engraftment. 
  • This explains why umbilical cord HSCT is not as commonly performed in adult oncology as in pediatric oncology (adult recipients weigh more).




Back to top