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Bone Marrow Transplant

 

 

Long Term Follow up Phase

Patient is discharged from hospital and followed closely in outpatient clinic (at first 2 to 3 times per week).

This period lasts for months to years. During this time the patient's immune system and bone marrow recovers.  Ongoing management consists of:

  • Gradually weaning off of immunosuppression
  • Management of Chronic GVHD

Transplants using T-cell depletion or from mismatched or haplotypic sources often have delayed or incomplete immune reconstitution.

Close monitoring of blood counts, signs and symptoms of infection or graft-versus-host disease, and adjusting of immune suppression.

Over months to years following HSCT both subspecialist HSCT physician and patient’s family doctor / pediatrician monitor patient for long-term complications of transplant.

Full immune reconstitution with the development of a proper adaptive immunity response takes 12-24 months following HSCT.  Therefore patients remain at risk for opportunistic infections during this time.  Development of cGVHD prolongs the process of immune reconstitution.

 

 

 

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