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Bone Marrow Transplant


TBI - Total Body Irradiation


Biologic Principles


  • There is minimal repair after damage to normal lymphoctes, represented by minimal shoulder on cell survival curve
  • Effective D0 about 3.8 Gy, the fractionated dose required by a given regimen to reduce the cell population to 37% on straight line portion of survival curve ( Shank, B Int J Radiat Oncol Biol Phys 9:  1613, 1983)

Leukemic cells:

  • Direct toxicity - also likely have minimal cell repair capacity, most fit the linear quadratic (LQ) model of cell survival (Lehnert et al.  Int J Radiat Biol 49: 423, 1986)  (Shank et al Radiother Oncol 27:  30, 1993)







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