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Late Effects





General Therapeutic Interventions:

  • Steroids (Inhaled and systemic)
  • Bronchodilators
  • Antibiotics
  • Oxygen


Empirical glucocorticoid therapy is usually initiated in a patient who has rapidly progressive or severe pulmonary toxicity, although evidence from randomized trials to support this practice is lacking.

Severe lung toxicity is characterized by:7

  • Dyspnea at rest
  • A decrease in oxygen saturation below 90%
  • Greater than a 4% decrease from baseline, worsening clinical status, or the need for ventilatory support.

Contraindications to glucocorticoids:7

  • Systemic fungal infection
  • Hypersensitivity to components of glucocorticoids

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