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Late Effects






It is common for survivors of childhood cancer to have long-term skin conditions related either to the therapy or the disease itself1 

Radiotherapy, Chemotherapy and underlying immune compromise all contribute to this problem5.

One long term study found that dermatological issues were reported by 59% of adult survivors of childhood cancers with 50% that saw a dermatologist at least once for these concerns5.

Skin conditions fall into the following broad categories:

  • Disease related:
    • Direct effect of primary tumor:
      • Cutaneous invasion and damage
  • Patient related:
  • Therapy related:
    • Graft vs Host disease (GvHD)
    • Secondary to Allografting
    • Infection secondary to immunosuppression:
      • Human papilloma virus can cause widespread warts which can be difficult to treat
      • Herpes simplex and herpes zoster infections can be prolonged with indolent ulcers
      • Mucocutaneous candidiasis usually occurs during therapy, but can be prolonged
      • Bacterial cellulitis: Streptococcal cellulitis is more common in the limbs of patients with lympedema as a long term consequence of cancer treatment and in immunocompromized patients
    • Side effects of primary therapy
      • Radiation therapy (RT)
      • Chemotherapy






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