Spleen and Immune System
Resources
Survivors and HCPs:
COG: General outline of problems associated with splenic dysfunction
COG Survivorship Guidelines: Precautions for people without a functional spleen
Post-splenectomy vaccine guideline
Immunizations for Patients With Lymphoma, Hodgkin Lymphoma, Myeloma and Leukemia (BCCA)
HCPs:
BC CDC: Immunization of special populations
NCI: Late Effects of the immune system
References:
1. Meadows AT, Obringer AC, Marrero O, et al: Second malignant neoplasms following childhood hodgkin's disease: Treatment and splenectomy as risk factors. Med Pediatr Oncol 17:477-484, 1989
2. Coleman CN, McDougall IR, Dailey MO, et al: Functional hyposplenia after splenic irradiation for hodgkin's disease. Ann Intern Med 96:44-47, 1982
3. Davidson RN, Wall RA: Prevention and management of infections in patients without a spleen. Clinical Microbiology & Infection 7:657-660, 2001
4. Kobel DE, Friedl A, Cerny T, et al: Pneumococcal vaccine in patients with absent or dysfunctional spleen. Mayo Clin Proc 75:749-753, 2000
5. Spelman D, Buttery J, Daley A, et al: Guidelines for the prevention of sepsis in asplenic and hyposplenic patients. Intern Med J 38:349-356, 2008
6. Fielding AK: Prophylaxis against late infection following splenectomy and bone marrow transplant. Blood Rev 8:179-191, 1994
7. Leung W, Neale G, Behm F, et al: Deficient innate immunity, thymopoiesis, and gene expression response to radiation in survivors of childhood acute lymphoblastic leukemia. Cancer Epidemiology 34:303-308, 2010
8. Brodtman DH, Rosenthal DW, Redner A, et al: Immunodeficiency in children with acute lymphoblastic leukemia after completion of modern aggressive chemotherapeutic regimens. J Pediatr 146:654-661, 2005
