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General sarcoma






Sarcomas are a very heterogenous group of tumors. 

Many specific cytogenetic abnormalities have been identified in different sarcomas.

The best resource to explore these further is the Atlas of Genetics and Cytogenetics in Oncology and Haematology.


Examples of tumor types and frequently found associated chromosomal translocations:

Tumor Associated translocation
Synovial sarcoma t(X;18)(p11.2;q11.2)
Alveolar rhabdomyosarcoma t(2;13)(q35;q14)
Myxoid liposarcoma t(12;16)(q13;p11)
Ewings sarcoma t(11;22)(q24;q12)
Desmoplastic small round cell tumor t(11;22)(p13;q11)
Clear cell sarcoma t(12;22)(q13;q12).
Alveolar soft part sarcomas t(X;17)(p11;q25)
Lipoblastoma clonal chromosomal rearrangements involving 8q11-13 region



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